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How To Bet This Week in College Hoops: Virginia-Duke, Arizona-Kansas, More

News RoomBy News RoomFebruary 28, 2026No Comments3 Mins Read
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The college basketball season has just a few weeks left, and NCAA Tournament positioning matters now more than ever. 

With that, let’s take a look at the odds for the biggest games on the schedule this week (at DraftKings Sportsbook as of Feb. 28), as well as what to know about each matchup. And check back throughout the week, as the games draw nearer and the odds update.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

MONDAY, FEB. 23

No. 24 Louisville 74, No. 18 UNC 77

Spread: Louisville -3.5 (UNC covers)
O/U: 162.5 (Under hits)

No. 5 Houston 56, No. 14 Kansas 69

Spread: Houston -1.5 (Kansas covers)
O/U: 138.5 (Under hits)

TUESDAY, FEB. 24

USC 62, UCLA 81

Spread: UCLA -7.5 (UCLA covers)
O/U: 150.5 (Under hits)

WEDNESDAY, FEB. 25

No. 15 St. John’s 40, No. 6 UConn 72

Spread: UConn -5.5 (UConn covers)
O/U: 145.5 (Under hits)

THURSDAY, FEB. 26 

No. 13 Michigan State 76, No. 8 Purdue 74

Spread: Purdue -7.5 (MSU covers)
O/U: 142.5 (Over hits)

What to know: Purdue has lost five of its last 10 and is 5-10 ATS as home favorites.

FRIDAY, FEB. 27

No. 3 Michigan 84, No. 10 Illinois 70

Spread: Michigan -2.5 (Michigan covers)
O/U: 160.5 (Under hits)

SATURDAY, FEB. 28

No. 11 Virginia @ No. 1 Duke

Spread: Duke -9.5
Moneyline: Duke -535, Virginia +400
O/U: 141.5

What to know: The Cavaliers are only a game behind the Blue Devils in the ACC standings. The two will only face off once this season, at Cameron Indoor, where the Dukies are 13-0 overall and as home favorites. 

No. 14 Kansas @ No. 2 Arizona

Spread: Arizona -9.5
Moneyline: Arizona -520, Kansas +390
O/U: 149.5

What to know: The Wildcats are 14-1 at home overall and as home favorites. Their lone home loss came against Texas Tech on Feb. 14, a game in which they were favored by nine (lost by three). Kansas is 2-2 as away underdogs.

No. 16 Texas Tech @ No. 4 Iowa State

Spread: ISU -10.5
Moneyline: ISU -575, TTU +425
O/U: 144.5

What to know: As favorites at home, the Cyclones are 8-6-1 ATS. They are 15-11-1 overall as favorites. The Red Raiders are just 11-11 ATS as favorites, but in conference games, they are 10-5 ATS.

No. 20 Arkansas @ No. 7 Florida

Spread: Florida -10.5
Moneyline: Florida -550, Arkansas +410
O/U: 170.5

What to know: The Gators are 11-4 ATS in conference play, but just 5-8 ATS as the home favorite. However, they are 12-1 overall as home favorites, with their lone loss coming to Auburn back on Jan. 24. Florida was an 11.5-point favorite in that game.

No. 9 Gonzaga @ Saint Mary’s

Spread: Gonzaga -1.5
Moneyline: Gonzaga -130, St. Mary’s +110
O/U: 143.5

What to know: A long-time WCC rivalry continues this weekend. Gonzaga was an 8.5-point home favorite against the Gaels back on Jan. 31, and failed to cover, winning by eight. The Bulldogs have covered in five of their last 10 games.

Read the full article here

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