MLB Opening Day 2025 starters: Which pitchers get the first call this season?

After the Tokyo Series between the Dodgers and Cubs last week, the 2025 MLB season gets underway on Thursday with Opening Day and a host of games across the country, starting at 3:00 p.m. ET and running until midnight. In addition, on Friday, March 28, the Rays and Rockies will face off at Tampa’s George M. Steinbrenner Field, also as part of the opening day of the 2025 MLB season

This is the guide to the games, times and openers for this whirlwind of baseball that Major League Baseball fans have been waiting at least five months for

Opening Day 2025: Schedule, matchups and starting pitchers

March 27

• Brewers at Yankees, 3:05 p.m. ET
• Freddy Peralta (MIL) vs. Carlos Rodon (NYY)

• Baltimore Orioles at Toronto Blue Jays, 3:07 p.m. ET
• Pitchers’ duel: Zach Eflin (BAL) vs. Jose Berrios (TOR)

• Red Sox at Rangers, 4:05 p.m. ET
• Garrett Crochet (BOS) vs. Nathan Eovaldi (TEX)

• Phillies at Nationals, 4:05 p.m. ET
• Zack Wheeler (PHI) vs. MacKenzie Gore (WSH)

• Guardians at Royals, 4:10 p.m. ET
• Tanner Bibee (CLE) vs. Cole Ragans (KC)

• Mets at Astros, 4:10 p.m. ET
• Clay Holmes (NYM) vs. Framber Valdez (HOU)

• Giants at Reds 4:10 p.m. ET
• Logan Webb (SF) vs. Hunter Greene (CIN)

• Braves at Padres, 4:10 p.m. ET
• Chris Sale (ATL) vs. Michael King (SD)

• Angels at White Sox 4:10 p.m. ET
• Yusei Kikuchi (LAA) vs. Sean Burke (CWS)

• Minnesota Twins at St. Louis Cardinals 4:15 p.m. ET
• Pablo Lopez (MIN) vs. Sonny Gray (STL)

• Tigers at Dodgers 19:10 ET
• Tarik Skubal (DET) vs. Blake Snell (SD)

• Cubs at D-backs, 10:10 p.m. ET
• Justin Steele (CHC) vs. Zac Gallen (AZ)

• Athletics at Mariners 22:10 ET
• Luis Severino (NYY) vs. Logan Gilbert (SEA)

March 28

• Rockies at Rays 4:10 p.m. ET
• Kyle Freeland (COL) vs. Ryan Pepiot (TB)