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College Football Week 12 Preview: Best Games to Watch this Weekend

News RoomBy News RoomNovember 14, 2025No Comments4 Mins Read
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The college football regular season is winding down, but there are still more than a handful of pivotal matchups left on the schedule.

Several of those games are on the upcoming Week 12 slate, and a few of the contests could help decide if certain premier squads make it into the College Football Playoff.

Let’s take a look at the best games to watch this weekend, with odds via DraftKings Sportsbook as of Nov. 13.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

(All times ET)

No. 18 Michigan @ Northwestern (noon, FOX)

Point spread: Michigan -10.5 (Michigan favored to win by more than 10.5 points, otherwise Northwestern covers)
Moneyline: Michigan -425 favorite to win; Northwestern +330 underdog to win
Total Over/Under: 41.5 points scored by both teams combined

What to know: The 7-2 Wolverines have won three straight since losing to USC. Northwestern, at 5-4, comes into this matchup on a two-game losing streak. While Michigan has the better outright record, Northwestern does have a big win over Penn State and was able to keep it close for one half in its 38-17 loss to USC.

No. 9 Notre Dame @ No. 22 Pittsburgh (noon, ABC)

Point spread: Notre Dame -12.5 (Notre Dame favored to win by more than 12.5 points, otherwise Pittsburgh covers)
Moneyline: Notre Dame -485 favorite to win; Pittsburgh +370 underdog to win
Total Over/Under: 54.5 points scored by both teams combined

What to know: Notre Dame dropped its first two games of the season but is now on a seven-game winning streak since those early losses. The Irish’s offense and defense both rank top 20 in the country. Pitt comes into this game on a four-game winning streak, including a 35-20 win over Stanford in Week 10 before its bye in Week 11. When it comes the big 12.5-point spread, bettors might want to note that Notre Dame is 4-5 against the spread (ATS) and Pitt is 7-2 in that spot.

No. 11 Oklahoma @ No. 4 Alabama (3:30 p.m., ABC)

Point spread: Alabama -6 (Alabama favored to win by more than 6 points, otherwise Oklahoma covers)
Moneyline: Alabama -225 favorite to win; Oklahoma +185 underdog to win
Total Over/Under: 45.5 points scored by both teams combined

What to know: As noted by Chris “The Bear” Fallica, Bama head coach Kalen DeBoer is 16-4 straight up (SU) in games decided by seven points or fewer as a Power 4 head coach. Another note to consider is that, as a Power 4 head coach, DeBoer is 17-2 SU against ranked teams. Perhaps the Sooners’ seventh-ranked defense can stop the Tide from rolling at Bryant-Denny.

No. 21 Iowa @ No. 17 USC (3:30 p.m., BTN)

Point spread: USC -7 (USC favored to win by more than 7 points, otherwise Iowa covers)
Moneyline: USC -245 favorite to win; Iowa +200 underdog to win
Total Over/Under: 48.5 points scored by both teams combined

What to know: USC is fighting for its playoff life, as the Trojans’ odds to make the CFP are +340. Iowa’s playoff hopes are effectively over and currently, the Hawkeyes are off that board. However, Iowa could play spoiler in L.A., as the Hawkeyes boast the sport’s fourth-ranked defense. The Trojans, though, have the sport’s second-best offense. 

No. 10 Texas @ No. 5 Georgia (7:30 p.m., ABC)

Point spread: Georgia -6.5 (Georgia favored to win by more than 6.5 points, otherwise Texas covers)
Moneyline: Georgia -238 favorite to win; Texas +195 underdog to win
Total Over/Under: 49.5 points scored by both teams combined

What to know: Georgia and Texas faced off twice in 2024, once in the regular season and again in the SEC Championship Game. The Dawgs won both matchups by scores of 30-15 and 22-19 (OT). Georgia is 8-1 on the season, with its only loss coming to Alabama; the Longhorns are 7-2, with losses to Ohio State and Florida. Kirby Smart & Co. are 4-5 ATS this year, while Burnt Orange comes into this contest 2-6-1 in that spot.

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