2025 NFL Odds Week 1: Lines, Spreads for all 16 Games

Alas, preseason is over. No more dress rehearsals. The real deal is here.

It’s time to start making some bets on real games.

The Super Bowl champion Philadelphia Eagles will kick off the 2025 season by hosting their NFC East rivals, the Dallas Cowboys, on Sept. 4.

With a loaded Week 1 slate, let’s check out the lines for each game at DraftKings Sportsbook as of Sept. 1. 

(All times ET)

2025 NFL Week 1 Odds

THURSDAY, SEPT. 4

COWBOYS @ EAGLES (8:20 p.m., NBC)

Point spread: Eagles -8.5 (Eagles favored to win by 8.5 points or more, otherwise Cowboys cover)
Moneyline: Eagles -395 favorites to win (bet $10 to win $12.53 total); Cowboys +310 underdogs to win (bet $10 to win $41 total)
Total Over/Under: 47.5 points scored by both teams combined

FRIDAY, SEPT. 5

CHIEFS @ CHARGERS (8:15 p.m., YouTube)

Point spread: Chiefs -3 (Chiefs favored to win by 3 points or more, otherwise Chargers cover)
Moneyline: Chiefs -170 favorites to win (bet $10 to win $15.88 total); Chargers +142 underdogs to win (bet $10 to win $24.20 total)
Total Over/Under: 45.5 points scored by both teams combined

SUNDAY, SEPT. 7

RAIDERS @ PATRIOTS (1 p.m., CBS)

Point spread: Patriots -3 (Patriots favored to win by 3 points or more, otherwise Raiders cover)
Moneyline: Patriots -155 favorites to win (bet $10 to win $16.45 total); Raiders +130 underdogs to win (bet $10 to win $23 total)
Total Over/Under: 43.5 points scored by both teams combined

STEELERS @ JETS (1 p.m., CBS)

Point spread: Steelers -3 (Steelers favored to win by 3 points or more, otherwise Jets cover)
Moneyline: Steelers -155 favorites to win (bet $10 to win $16.45 total); Jets +130 underdogs to win (bet $10 to win $23 total)
Total Over/Under: 38.5 points scored by both teams combined

DOLPHINS @ COLTS (1 p.m., CBS)

Point spread: Colts -1.5 (Colts favored to win by 1.5 points or more, otherwise Dolphins cover)
Moneyline: Colts -112 favorites to win (bet $10 to win $18.93 total); Dolphins -108 underdogs to win (bet $10 to win $19.26 total)
Total Over/Under: 47.5 points scored by both teams combined

CARDINALS @ SAINTS (1 p.m., CBS)

Point spread: Cardinals -6.5 (Cardinals favored to win by 6.5 points or more, otherwise Saints cover)
Moneyline: Cardinals -285 favorites to win (bet $10 to win $13.51 total); Saints +230 underdogs to win (bet $10 to win $33 total)
Total Over/Under: 43.5 points scored by both teams combined

GIANTS @ COMMANDERS (1 p.m., FOX and FOX Sports app)

Point spread: Commanders -6 (Commanders favored to win by 6 points or more, otherwise Giants cover)
Moneyline: Commanders -265 favorites to win (bet $10 to win $13.77 total); Giants +215 underdogs to win (bet $10 to win $31.50 total)
Total Over/Under: 45.5 points scored by both teams combined

PANTHERS @ JAGUARS (1 p.m., FOX and FOX Sports app)

Point spread: Jaguars -3.5 (Jaguars favored to win by 3.5 points or more, otherwise Panthers cover)
Moneyline: Jaguars -180 favorites to win (bet $10 to win $15.56 total); Panthers +150 underdogs to win (bet $10 to win $25 total)
Total Over/Under: 46.5 points scored by both teams combined

BENGALS @ BROWNS (1 p.m., FOX and FOX Sports app)

Point spread: Bengals -5.5 (Bengals favored to win by 5.5 points or more, otherwise Browns cover)
Moneyline: Bengals -238 favorites to win (bet $10 to win $14.20 total); Browns +195 underdogs to win (bet $10 to win $29.50 total)
Total Over/Under: 47.5 points scored by both teams combined

BUCCANEERS @ FALCONS (1 p.m., FOX and FOX Sports app)

Point spread: Buccaneers -2.5 (Buccaneers favored to win by 2.5 points or more, otherwise Falcons cover)
Moneyline: Buccaneers -135 favorites to win (bet $10 to win $17.41 total); Falcons +114 underdogs to win (bet $10 to win $21.40 total)
Total Over/Under: 47.5 points scored by both teams combined

TITANS @ BRONCOS (4:05 p.m., FOX and FOX Sports app)

Point spread: Broncos -7.5 (Broncos favored to win by 7.5 points or more, otherwise Titans cover)
Moneyline: Broncos -380 favorites to win (bet $10 to win $12.63 total); Titans +300 underdogs to win (bet $10 to win $40 total)
Total Over/Under: 42.5 points scored by both teams combined

49ERS @ SEAHAWKS (4:05 p.m., FOX and FOX Sports app)

Point spread: 49ers -2.5 (49ers favored to win by 2.5 points or more, otherwise Seahawks cover)
Moneyline: 49ers -135 favorites to win (bet $10 to win $17.41 total); Seahawks +114 underdogs to win (bet $10 to win $21.40 total)
Total Over/Under: 43.5 points scored by both teams combined

LIONS @ PACKERS (4:25 p.m., CBS)

Point spread: Packers -2.5 (Packers favored to win by 2.5 points or more, otherwise Lions cover)
Moneyline: Packers -148 favorites to win (bet $10 to win $16.76 total); Lions +124 underdogs to win (bet $10 to win $22.40 total)
Total Over/Under: 46.5 points scored by both teams combined

TEXANS @ RAMS (4:25 p.m., CBS)

Point spread: Rams -3 (Rams favored to win by 3 points or more, otherwise Texans cover)
Moneyline: Rams -155 favorites to win (bet $10 to win $16.45 total); Texans +130 underdogs to win (bet $10 to win $23 total)
Total Over/Under: 43.5 points scored by both teams combined

RAVENS @ BILLS (8:20 p.m., NBC)

Point spread: Bills -1.5 (Bills favored to win by 1.5 points or more, otherwise Ravens cover)
Moneyline: Bills -112 favorites to win (bet $10 to win $18.93 total); Ravens -108 underdogs to win (bet $10 to win $19.26 total)
Total Over/Under: 50.5 points scored by both teams combined 

MONDAY, SEPT. 8

VIKINGS @ BEARS (8:15 p.m., ESPN)

Point spread: Vikings -1.5 (Vikings favored to win by 1.5 points or more, otherwise Bears cover)
Moneyline: Vikings -125 favorites to win (bet $10 to win $18 total); Bears +105 underdogs to win (bet $10 to win $20.50 total)
Total Over/Under: 44.5 points scored by both teams combined

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