The 2025 MLB regular season had a historic start in Tokyo, on March 18. However, Opening Day is officially scheduled for this Thursday, March 27, the earliest date in Major League Baseball history.
Each team prepares to embark on their journey toward glory, while fans around the world gear up to witness the matchups that will define the early chapters of the championship race.
In this guide, you’ll find the complete schedule, matchups, and start times for every game that kicks off the 2025 MLB season. Get ready to enjoy the action, rivalry, and stories that make MLB unique.
MLB Opening Day 2025 schedule
While for MLB Opening Day, there is an extensive schedule of games, from 3:05 p.m. ET until midnight on Friday. Here is the full schedule:
- Milwaukee Brewers vs. New York Yankees – 3:05 p.m. ET/12:05 p.m. PT
- Baltimore Orioles vs. Toronto Blue Jays – 15:07 ET/12:07 PT
- Philadelphia Phillies vs. Washington Nationals – 4:05 p.m. ET/1:05 p.m. PT
- Boston Red Sox vs. Texas Rangers – 4:05 p.m. ET/1:05 p.m. PT
- Cleveland Guardians vs. Kansas City Royals – 16:10 ET/13:10 PT
- Atlanta Braves vs. San Diego Padres – 4:10 p.m. ET/1:10 p.m. PT
- San Francisco Giants vs. Cincinnati Reds – 16:10 ET/13:10 PT
- Pittsburgh Pirates vs. Miami Marlins – 4:10 p.m. ET/1:10 p.m. PT
- Los Angeles Angels vs. Chicago White Sox – 4:10 p.m. ET/1:10 p.m. PT
- New York Mets vs. Houston Astros – 4:10 p.m. ET/1:10 p.m. PT
- Minnesota Twins vs. St. Louis Cardinals 4:15 p.m. ET/1:15 p.m. PT
- Detroit Tigers vs. Los Angeles Dodgers 7:10 p.m. ET/4:10 p.m. PT
- Oakland Athletics vs. Seattle Mariners – 10:10 p.m. ET/7:10 p.m. PT
- Chicago Cubs vs. Arizona Diamondbacks – 10:10 p.m. ET/7:10 p.m. PT
Friday, March 28
- Colorado Rockies vs. Tampa Bay Rays – 4:10 p.m. ET/1:10 p.m. PT
How to watch MLB Opening Day 2025 games
Most of the games will be broadcast by the regional networks affiliated with each club.
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