Fantasy football is a game of strategy, statistics and a bit of luck. However, nothing impacts more than injuries to the most reliable players.
This fourth week of the 2025 season turned into a real earthquake for those who relied on offensive figures who will now be out for weeks.
NFL injury list
Vikings:
- QB J.J. McCarthy (ankle)
- TE Ben Yurosek (knee)
- OL Donovan Jackson (wrist)
- LB Andrew Van Ginkel
Steelers:
- LB Alex Highsmith (ankle)
- RB Jaylen Warren (knee)
- TE Jonnu Smith (hip)
- CB Joey Porter Jr. (hamstring)
Falcons:
- WR KhaDarel Hodge (groin)
- CB A.J. Terrell (hamstring)
Panthers:
- WR Xavier Legette (hamstring)
- TE Ja’Tavion Sanders (ankle)
- LB Patrick Jones II (hamstring)
- LB D.J. Wonnum (hip)
Seahawks:
- OT Josh Jones (ankle)
- S Nick Emmanwori (ankle)
- RB Zach Charbonnet (foot)
- G Anthony Bradford (back)
- LB Boye Mafe (toe)
Cardinals:
- WR Zay Jones (concussion)
- CB Will Johnson (English)
- G Evan Brown (ankle)
- G Will Hernandez (knee)
- OT Kelvin Beachum (knee)
- OT Paris Johnson Jr. (knee)
- LB Akeem Davis-Gaither (elbow)
- CB Darren Hall (ankle)
Quarterbacks on the tightrope
One of the biggest blows came with the injury to C.J. Stroud, quarterback for the Houston Texans, who left with a shoulder injury. Although the team is still evaluating his status, the risk of him missing games creates uncertainty for Fantasy managers who relied on his consistent aerial production.
On the other hand, Anthony Richardson of the Indianapolis Colts once again set off alarm bells with knee problems. His explosiveness as a runner made him a gem in Fantasy leagues, but concerns about durability remain.
Running backs who change the equation
The hardest hit area was the running backs. Bijan Robinson, star of the Atlanta Falcons, left the game with muscle discomfort. His starring role in the offense makes him a painful loss for both the team and thousands of Fantasy users.
Also, Saquon Barkley of the New York Giants again had ankle problems. Although the medical report is not yet definitive, any absence of Barkley could collapse Fantasy rosters that depend on his yards and touchdowns.
Receivers under observation
Among the wide receivers, the concern was focused on Justin Jefferson, who suffered a leg sprain. The Minnesota Vikings did not confirm the severity, but the simple fact that the best receiver in the league is in doubt is enough to alter Fantasy rankings across the country.
Another name that is causing a stir is Jaylen Waddle of the Miami Dolphins, who went out with a hip injury. His speed and connection with Tua Tagovailoa makes him a key piece of any Fantasy strategy.
What should Fantasy Football players do?
Week 4 is a reminder that in fantasy, it’s not just the initial draft that matters, but the ability to adapt. Checking waivers, looking for strategic replacements and keeping a close eye on medical reports will be crucial. Backup running backs and secondary receivers can become temporary saviors for those who quickly adjust their lineups.
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