Serena Williams injects herself with a GLP-1 drug to lose weight while millions of people watch the Super Bowl. The 44-year-old former tennis player recalls in the controversial ad that GLP-1 can be obtained in pill form in the Ro app.
What is the GLP-1 that Serena Williams injects during the Super Bowl?
GLP-1 (glucagon-like peptide-1) is a hormone naturally produced in the gut that regulates blood sugar and appetite.
Its main functions would be glucose control, prolonged satiety and slow digestion.
The most famous brand names for consuming GLP-1 are Semaglutide (known as Ozempic (diabetes) or Wegovy (obesity)) and Tirzepatide (Mounjaro or Zepbound).
He never managed to reach the weight he needed, no matter what he did or how much he trained
The expert doctors of the United States Food and Drug Administration (FDA) gave the expected green light to Zepbound, the drug tirzepatide, on November 8, 2023.
The drug that helped Serena Williams lose 14 kilos: the fights over her overweight
Serena Williams, winner of 23 Grand Slams, shared in September 2025 that she had lost 14 kilos in the last year, and admitted that she used the drug Zepbound with GLP-1 in her weight loss process.
It was very frustrating to do the same thing over and over again and never be able to change the scale or the appearance of my body
“I could never reach the weight I needed, no matter what I did or how hard I trained. It was crazy because never in my life had I been in a situation like that, where I was working so hard, eating so healthy and never getting to my ideal weight,” Serena Williams told People.
Serena shared that the drug Zepbound helped her improve her healthy routines and exercise: “I never took shortcuts in my career and I always worked very hard. I know what it takes to be the best. So it was very frustrating to always do the same thing and never be able to change the scale or the look of my body.”
The 44-year-old tennis player began to struggle with her weight after becoming a mother for the first time in 2017, and also suffered postpartum problems after the birth of her second daughter in 2023.
Patrick Mouratoglou, Serena Williams’ former coach, has revealed the discussions he had with the tennis player about her being overweight to compete after pregnancies.
“I remember it very well. It was after the pregnancy; I know these things take time. I said, ‘Look, this is not a comment about your appearance. It’s not my problem… ‘ We had some discussions. I remember she didn’t like me saying that because she thought I was judging her. But I insisted: ‘I don’t care what you look like,'” he told ‘Today‘.
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